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KMID : 1038620140320010043
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Radiation Oncology Journal
2014 Volume.32 No. 1 p.43 ~ p.47
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CT-based quantitative evaluation of radiation-induced lung fibrosis: a study of interobserver and intraobserver variations
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Heo Jae-Sung
Cho O-Yeon
Noh O-Kyu
Oh Young-Taek
Chun Mi-Son
Park Hae-Jin
Kim Mi-Hwa
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Abstract
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Purpose: The degree of radiation-induced lung fibrosis (RILF) can be measured quantitatively by fibrosis volume (VF) on chest computed tomography (CT) scan. The purpose of this study was to investigate the interobserver and intraobserver variability in CT-based measurement of VF.
Materials and Methods: We selected 10 non-small cell lung cancer patients developed with RILF after postoperative radiation therapy (PORT) and delineated VF on the follow-up chest CT scanned at more than 6 months after radiotherapy. Three radiation oncologists independently delineated VF to investigate the interobserver variability. Three times of delineation of VF was performed by two radiation oncologists for the analysis of intraobserver variability. We analysed the concordance index (CI) and inter/intra-class correlation coefficient (ICC).
Results: The median CI was 0.61 (range, 0.44 to 0.68) for interobserver variability and the median CIs for intraobserver variability were 0.69 (range, 0.65 to 0.79) and 0.61(range, 0.55 to 0.65) by two observers. The ICC for interobserver variability was 0.974 (p < 0.001) and ICCs for intraobserver variability were 0.996 (p < 0.001) and 0.991 (p < 0.001), respectively.
Conclusion: CT-based measurement of VF with patients who received PORT was a highly consistent and reproducible quantitative method between and within observers.
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KEYWORD
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Radiation-induced lung fibrosis, Fibrosis volume, Quantitative CT, Interobserver variation, Intraobserver variation
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